2024-03-28T23:49:59Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/249792021-12-28T16:06:01Zcom_10261_103com_10261_1col_10261_356
Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
Lalic, Jasna
Agudelo-Romero, Patricia
Carrasco, Purificación
Elena, Santiago F.
virus evolution
emerging viruses
local adaptation
Tobacco etch virus
specialism
generalism
Viral pathogens continue to emerge among humans, domesticated animals and cultivated crops. The existence of genetic variance for resistance in the host population is crucial to the spread of an emerging virus. Models predict that rapid spread decreases with the frequency and diversity of resistance alleles in the host population. However, empirical tests of this hypothesis are scarce. Arabiodpsis thaliana – Tobacco etch potyvirus (TEV) provides an experimentally suitable pathosystem for explore the interplay between genetic variation in host’s susceptibility and virus diversity. Systemic infection of A. thaliana with TEV is controlled by three dominant loci, with different ecotypes varying in susceptibility depending on the genetic constitution at these three loci. Here, we show that TEV adaptation to a susceptible ecotype allowed the virus to successfully infect, replicate and induce symptoms in ecotypes that were fully resistant to the ancestral virus. The value of these results is two-fold. First, we showed that the existence of partially susceptible individuals allows for the emerging virus to bypass resistance alleles that the virus has never encountered. Second, the concept of resistance genes may only be valid for a well-defined viral genotype but not for polymorphic viral populations.
2010-06-02T18:00:15Z
2010-06-02T18:00:15Z
2010-05-17
artículo
Philosophical Transactions - B - Biological Sciences
http://hdl.handle.net/10261/24979
10.1098/rstb.2010.0044
20478894
eng
Phil. Trans. R. Soc. B
365: 1997-2008
http://rstb.royalsocietypublishing.org/content/365/1548/1997.full.pdf+html
openAccess
Royal Society (Great Britain)