2024-03-29T05:55:05Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/248912018-08-14T12:30:09Zcom_10261_79com_10261_1col_10261_332
Surveillance of antibiotic resistance evolution and detection of class 1 and 2 integrons in human isolates of multi-resistant Salmonella Typhimurium obtained in Uruguay between 1976 and 2000.
Macedo-Viñas, Marina
Cordeiro, Nicolás F.
Bado, Inés
Herrera-León, Silvia
Vola, Magdalena
Robino, Luciana
González-Sanz, Rubén
Mateos, Soledad
Schelotto, Felipe
Algorta, Gabriela
Ayala, Juan Alfonso
Echeita, Aurora
Vignoli, Rafael
Salmonella
Antibiotics
Resistance
Integrons
Evolution
[Objectives] To study the evolution of antibiotic resistance in isolates of Salmonella enterica
subspecies enterica serovar Typhimurium (Salmonella Typhimurium) obtained in Uruguay between
the years 1976 and 2000, and to determine the incidence of class 1 and 2 integrons in the multiresistant
isolates.
[Methods] We studied 258 strains of Salmonella Typhimurium from various sources, isolated
between 1976 and 2000. We determined the evolution of antibiotic resistance and the distribution
of class 1 and 2 integrons in all isolates by means of disk diffusion assays and PCR.
[Results] During the period 1989—2000 resistance to streptomycin was 56.8%, tetracycline 13.6%,
sulfonamides 11.2%, and ampicillin 7.2%. Resistance to gentamicin, kanamycin, chloramphenicol,
and nalidixic acid were lower than 5%; no resistance was detected to fluoroquinolones, oxyiminocephalosporins,
and amikacin. These results show a dramatic decrease with respect to values
found in the period 1976—1988. In this period, resistance to streptomycin was 63.2%, tetracycline
36.8%, sulfonamides 32.3%, and ampicillin 27.8%. Throughout the two periods, 29 multi-resistant
2010-05-31T15:16:49Z
2010-05-31T15:16:49Z
2009-05-13
artículo
Int J Infect Dis.13(3):342-8 (2009)
1201-9712
http://hdl.handle.net/10261/24891
10.1016/j.ijid.2008.07.012
18977678
eng
http://dx.doi.org/10.1016/j.ijid.2008.07.012
openAccess
Elsevier