2024-03-28T10:23:26Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2004332022-05-10T09:03:58Zcom_10261_54com_10261_1col_10261_307
Acetylcholine Facilitates a Depolarization-Induced Enhancement of Inhibition in Rat CA1 Pyramidal Neurons
Domínguez, Soledad
Fernández de Sevilla, D.
Buño, Washington
Ministerio de Ciencia y Tecnología (España)
Comunidad de Madrid
Ministerio de Economía y Competitividad (España)
CSIC - Instituto Cajal (IC)
Centre National de la Recherche Scientifique (France)
Université de Paris
Universidad Autónoma de Madrid
Cytosolic Ca2+
GABAA-LTP
GPCR activity
Negative feedback
α5βγ2-GABAARs
Cholinergic mechanisms in the hippocampus regulate forms of synaptic plasticity linked with cognition and spatial navigation, but the underlying mechanisms remain largely unknown. Here, in rat hippocampal CA1 pyramidal cells under blockade of ionotropic glutamate receptors, we report that a single acetylcholine pulse and repeated depolarization activated a robust and enduring postsynaptic depolarization-induced enhancement of inhibition (DEI) that masked a presynaptic depolarization-induced suppression of inhibition (DSI). Increased cytosolic Ca2+ and M1-muscarinic receptor activation caused the rise in voltage-sensitive α5βγ2-containing γ-aminobutyric acid type-A receptors that generated DEI. In summary, this muscarinic-mediated activity-dependent plasticity rapidly transfers depolarization effects on inhibition from presynaptic suppression or DSI to postsynaptic enhancement or DEI, a change potentially relevant in behavior.
2020-02-12T12:31:30Z
2020-02-12T12:31:30Z
2017-01
2020-02-12T12:31:30Z
artículo
Cerebral Cortex 27(1): 852-862 (2017)
1047-3211
http://hdl.handle.net/10261/200433
10.1093/cercor/bhv276
1460-2199
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100004794
http://dx.doi.org/10.13039/501100004593
http://dx.doi.org/10.13039/501100006280
http://dx.doi.org/10.1093/cercor/bhv276
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-43668-P
closedAccess
Oxford University Press