2024-03-29T08:36:41Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1850442019-10-05T01:08:53Zcom_10261_64com_10261_1col_10261_317
The potential role of genomic medicine in the therapeutic management of rheumatoid arthritis
Acosta-Herrera, Marialbert
González-Serna, David
Martín, Javier
Instituto de Salud Carlos III
Ministerio de Economía y Competitividad (España)
Rheumatoid arthritis
Pharmacogenomics
Methotrexate
Anti-TNF
Personalized medicine
© The Author(s).
During the last decade, important advances have occurred regarding understanding of the pathogenesis and treatment of rheumatoid arthritis (RA). Nevertheless, response to treatment is not universal, and choosing among different therapies is currently based on a trial and error approach. The specific patient’s genetic background influences the response to therapy for many drugs: In this sense, genomic studies on RA have produced promising insights that could help us find an effective therapy for each patient. On the other hand, despite the great knowledge generated regarding the genetics of RA, most of the investigations performed to date have focused on identifying common variants associated with RA, which cannot explain the complete heritability of the disease. In this regard, rare variants could also contribute to this missing heritability as well as act as biomarkers that help in choosing the right therapy. In the present article, different aspects of genetics in the pathogenesis and treatment of RA are reviewed, from large-scale genomic studies to specific rare variant analyses. We also discuss the shared genetic architecture existing among autoimmune diseases and its implications for RA therapy, such as drug repositioning
2019-06-28T06:40:43Z
2019-06-28T06:40:43Z
2019-06-10
2019-06-28T06:40:43Z
artículo
Journal of Clinical Medicine 8(6): 826 (2019)
http://hdl.handle.net/10261/185044
2077-0383
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100003329
Publisher’s version
https://doi.org/10.3390/jcm8060826
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-66761-P
http://creativecommons.org/licenses/by/4.0/
openAccess
Multidisciplinary Digital Publishing Institute