2024-03-28T17:48:16Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1651522020-12-10T16:18:53Zcom_10261_134com_10261_1col_10261_387
A role for the host in the roadmap to diabetes stem cell therapy
Soria Escoms, Bernat
Montanya, Eduard
Martín, Franz
Hmadcha, Abdelkrim
Stem cells represent an unlimited source for cell therapy, and considerable efforts have been made to overcome barriers to introducing this revolutionary therapy into
clinical practice. Briefly, the following actions must be taken: 1) design in vitro differentiation strategies to generate either mature postmitotic b-cells or b-cell progenitors that may be safely implanted into the host (e.g., without uncontrolled proliferation), 2) devise selection methods to produce a pure b-cell population, 3) validate standard characterization protocols to determine the real differentiation stage of the cells ready to be transplanted, 4) obtain encapsulation devices to implant the cells, 5) develop preclinical controls in representative animal models, and 6) define cell-host interactions.
2018-05-25T12:57:24Z
2018-05-25T12:57:24Z
2016
2018-05-25T12:57:24Z
artículo
Diabetes 65(5): 1155-1157 (2016)
http://hdl.handle.net/10261/165152
10.2337/dbi16-0003
27208184
eng
Sí
closedAccess
American Diabetes Association