2024-03-29T05:33:29Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1345672018-09-07T06:58:10Zcom_10261_112com_10261_1col_10261_365
Synthesis and evaluation as antitumor agents of 1,4-naphthohydroquinone derivatives conjugated with amino acids and purines
Molinari, Aurora
Castro, M. Ángeles
Mollinedo, Faustino
European Commission
Comisión Nacional de Investigación Científica y Tecnológica (Chile)
Junta de Castilla y León
Pontificia Universidad Católica de Valparaíso
Antineoplastic
Hydroquinone–purine
Hydroquinone–amino acid
Hybrids
Cytotoxicity
We report on the synthesis of two series of 1,4-naphthohydroquinone derivatives conjugated with amino acids (Gly, Ala, Phe, and Glu) and with substituted purines linked by an aliphatic chain. The compounds were obtained through Diels-Alder cycloaddition between myrcene and 1,4-benzoquinone and evaluated in vitro for their cytotoxicity (GI50) against cultured human cancer cells of A-549 lung carcinoma, HT-29 colon adenocarcinoma, and MCF-7 breast carcinoma. The GI50 values found for some hydroquinone-amino acid and hydroquinone-purine hybrids against MCF-7 are in an activity range comparable to that of the reference drug doxorubicin.
2016-07-07T09:50:30Z
2016-07-07T09:50:30Z
2013
2016-07-07T09:50:30Z
artículo
Archiv der Pharmazie 346(12): 882-890 (2013)
http://hdl.handle.net/10261/134567
10.1002/ardp.201300137
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100002848
http://dx.doi.org/10.13039/501100007776
http://dx.doi.org/10.13039/501100014180
eng
Sí
closedAccess
Wiley-VCH