2024-03-29T05:43:08Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/119032022-05-27T09:39:26Zcom_10261_25com_10261_1col_10261_278
The neglected intrinsic resistome of bacterial pathogens
Fajardo, Alicia
Martínez-Martín, Nadia
Mercadillo, María
Galán, Juan Carlos
Ghysels, Bart
Matthijs, Sandra
Cornelis, Pierre
Wiehlmann, Lutz
Tümmler, Burkhard
Baquero, Fernando
Martínez, José L.
Antibiotic resistance genes
Bacterial pathogens
Mutation-driven acquisition
Pseudomonas aeruginosa
Antibiotic susceptibility
Resistance prediction
6 pages, 2 figures, 2 tables.-- PMID: 18286176 [PubMed].-- PMCID: PMC2238818.
Supporting information (Suppl. table S1) available at: http://www.plosone.org/article/fetchSingleRepresentation.action?uri=info:doi/10.1371/journal.pone.0001619.s001
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets. Mutations in other genes make P. aeruginosa more resistant and therefore define novel mechanisms for mutation-driven acquisition of antibiotic resistance, opening a new research field based in the prediction of resistance before it emerges in clinical environments. Antibiotics are not just weapons against bacterial competitors, but also natural signalling molecules. Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature.
2009-03-27T13:36:12Z
2009-03-27T13:36:12Z
2008-02-20
artículo
PLoS ONE 3(2): e1619 (2008)
1932-6203
http://hdl.handle.net/10261/11903
10.1371/journal.pone.0001619
18286176
eng
Publisher’s version
http://dx.doi.org/10.1371/journal.pone.0001619
openAccess
Public Library of Science