2024-03-29T09:22:04Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/336312021-07-12T07:18:39Zcom_10261_81com_10261_5col_10261_334
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity
Alonso De Diego, Sergio A.
Gutiérrez-Rodríguez, Marta
Pérez de Vega, M. Jesús
González-Muñiz, Rosario
Herranz, Rosario
Martín-Martínez, Mercedes
Cenarruzabeitia, Edurne
Frechilla, Diana
Río, Joaquín del
Jimeno, M. Luisa
García-López, M. Teresa
Neuroprotection
Glutamate receptors binding
Tripeptides
Peptidomimetics
GPE
The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.
This work has been supported by the Spanish Ministry of Education and Science (SAF 2003-07207-C02) and Comunidad de Madrid (GR/SAL/0850/2004), and UTE project FIMA. S.A.A.D.D. holds a predoctoral fellowship from the Ministry of Education for Associated Units to CSIC.
Peer reviewed
2011-03-21T12:09:32Z
2011-03-21T12:09:32Z
2006-07-01
artículo
http://purl.org/coar/resource_type/c_6501
Bioorganic & Medicinal Chemistry Letters 16(13): 3396-3400 (2006)
0960-894X
http://hdl.handle.net/10261/33631
10.1016/j.bmcl.2006.04.033
en
http://dx.doi.org/10.1016/j.bmcl.2006.04.033
none
Elsevier