2024-03-28T11:43:04Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1730292021-12-28T15:44:14Zcom_10261_5062com_10261_5col_10261_5064
Prenatal exposure to persistent organic pollutants and anogenital distance in children at 18 months
García-Villarino, Miguel
Riaño-Galán, Isolina
Rodríguez Dehli, Ana Cristina
Vizcaino, Esther
Grimalt, Joan O.
Tardón, Adonina G.
Fernández-Somoano, Ana
DEHP metabolites
Phthalic Acids
Diethylhexyl Phthalate
Background: Anogenital distance (AGD) is a measure of in utero exposure to hormonally active agents. The aim of the present study was to evaluate the association between prenatal exposure to persistent organic pollutants (POPs) and AGD. Methods: POP levels were measured in pregnant women, and the AGD was recorded in 43 offspring at 18 months. We used linear regression models to analyze the association between maternal POP exposure and offspring AGD. We defined the anogenital index (AGI) as AGD divided by weight at 18 months (AGI = AGD / weight at 18 months [mm/kg]) and included this variable in the regression models. Results: AGI measure was 2.35 (0.61) and 1.38 (0.45) in males and females, respectively. AGI was inversely associated with lipid-adjusted concentrations of PBDE-99 (β = -0.28, 95% confidence interval [CI]: -0.51, -0.04) and PBDE-153 (β = -0.61, 95% CI: -1.11, -0.11) in males. We did not find any statistically significant relationship between any POPs and AGI in females. Conclusions: Environmental exposure to POPs may affect genital development and result in reproductive tract alterations with potentially relevant health consequences in maturity. © 2018 The Author(s). Published by S. Karger AG, Basel.
This study was funded by grants from FIS-FEDER (PI04/2018, PI09/02311, and PI13/02429), Fundación Cajastur-Liberbank, and Universidad de Oviedo.
Peer reviewed
2018-12-07T08:59:14Z
2018-12-07T08:59:14Z
2018-10-01
artículo
http://purl.org/coar/resource_type/c_6501
Hormone Research in Paediatrics 90(2): 116-122 (2018)
http://hdl.handle.net/10261/173029
10.1159/000492236
30212819
en
Publisher's version
https://doi.org/10.1159/000492236
Sí
open
S. Karger AG