2024-03-28T13:37:28Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1727172020-08-07T09:05:56Zcom_10261_70com_10261_2col_10261_449
Effect on metabolic syndrome markers of an 8-week supplementation with grape pomace in subjects at high cardiometabolic risk
Martínez-Maqueda, D.
Vaquero, M. Pilar
Zapatera, Belén
Gallego-Narbón, Angélica
Saura Calixto, Fulgencio D.
Pérez-Jiménez, Jara
Ministerio de Economía y Competitividad (España)
Resumen del trabajo presentado al ILSI Europe's Annual Symposium celebrado en Bruselas (Bélgica) el 27 de marzo de 2018.
The increasing occurrence of metabolic syndrome (MetS) in developed countries is one of the most important current public health challenges. Polyphenols have shown a promising role in their modulation mostly in preclinical studies, although clinical trials are still scarce and with contradictory results1. Moreover, they usually only consider a fraction of polyphenols, ignoring non-extractable polyphenols2. The aim of this study was to evaluate the effect on MetS markers and related biochemical parameters of the long-term supplementation with grape pomace, an abundant vinification byproduct rich in both extractable and non-extractable polyphenols. Fifty subjects (22 women) aged 20-65 with high cardiometabolic risk (at least two MetS factors, mean 2.7 SEM 0.2) were randomly assigned to the product (daily consumption of 8 g of dried and milled grape pomace) or to the control group in a 6 weeks crossover design with a 4 weeks wash-out. Samples were collected at the beginning and at the end of both periods. Preliminary results indicate an amelioration of postprandial (120 min after glucose load) insulinaeamia after supplementation (50.8 SE 10.6 vs 61.8 SEM 12.3 μU/mL) with no modifications in other cardiometabolic risk factors. Therefore, supplementation with grape pomace may be a strategy for improving insulin sensitivity in subjects at high cardiometabolic risk.
Research funded by the Spanish Ministry of Economy and Competitiveness (AGL2014-55102-JIN).
Peer Reviewed
2018-11-27T13:35:15Z
2018-11-27T13:35:15Z
2018
2018-11-27T13:35:15Z
comunicación de congreso
http://purl.org/coar/resource_type/c_5794
ILSI Europe's Annual Symposium (2018)
http://hdl.handle.net/10261/172717
http://dx.doi.org/10.13039/501100003329
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-55102-JIN
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