2024-03-28T16:36:48Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/121492018-08-13T08:48:38Zcom_10261_69com_10261_2col_10261_322
Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
Erny, Guillaume L.
Cifuentes, Alejandro
Biological fluids
LC–MS
CE–MS
Enantiomers
Drugs
Capillary electrophoresis
Hyphenated techniques
Liquid chromatography
Metabolites
Sample preparation
CEC–MS
Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc, of pharmaceuticals. In this manuscript, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including e.g., antiinflammatories, antihypertensives, relaxants, etc, by liquid chromatography-mass spectrometry and capillary electrophoresis-mass spectrometry are included. The importance and interest of the analysis of the enantiomers of the active compound and its metabolites in different biological fluids (plasma, urine, cerebrospinal fluid, etc) are also discussed.
Peer reviewed
2009-04-06T16:09:09Z
2009-04-06T16:09:09Z
2006-02
artículo
http://purl.org/coar/resource_type/c_6501
Journal of Pharmaceutical and Biomedical Analysis, Volume 40, Issue 3, Pages 509-515
0731-7085
http://hdl.handle.net/10261/12149
10.1016/j.jpba.2005.10.044
en
http://dx.doi.org/10.1016/j.jpba.2005.10.044
open
163062 bytes
application/pdf
Elsevier