2024-03-29T13:57:35Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/74892021-12-27T15:55:49Zcom_10261_2855com_10261_4com_10261_91com_10261_8col_10261_2857col_10261_344
Cartwright, Julyan H. E.
Piro, Oreste
Tuval, Idan
2008-10-03T11:30:43Z
2008-10-03T11:30:43Z
2004-05-11
Proceedings of the National Academy of Sciences of the USA (PNAS) 101(19): 7234-7239 (2004)
0027-8424
http://hdl.handle.net/10261/7489
10.1073/pnas.0402001101
15118088
Experimental work in developmental biology has recently shown in mice that fluid flow driven by rotating cilia in the node, a structure present in the early stages of growth of vertebrate embryos, is responsible for determining the normal development of the left--right axis, with the heart on the left of the body, the liver on the right, and so on. The role of physics, in
particular of fluid dynamics, in the process, is one of the important questions that remain to be answered. We show with an analysis of the fluid dynamics of the nodal flow in the developing embryo that the leftward flow that has been
experimentally observed may be produced by the monocilia driving it being tilted toward the posterior. We propose a model for morphogen transport and mixing in the nodal flow, and discuss how this might initiate the development
of left--right asymmetry.
eng
closedAccess
Physics
Developmental biology
Fluid-dynamical basis of the embryonic development of left right asymmetry in vertebrates
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