2024-03-29T13:34:07Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/730342019-03-11T10:25:01Zcom_10261_54com_10261_1col_10261_307
Cerro, Sonia del
Borrell, José
2013-03-26T16:03:40Z
2013-03-26T16:03:40Z
1988
Psychopharmacology 94: 227-231 (1988)
0033-3158
http://hdl.handle.net/10261/73034
10.1007/BF00176850
The possible involvement of endogenous opioid peptides in the development of the facilitatory effect of adrenaline on memory has been investigated. For this purpose post-training administration of adrenaline and/or naloxone was carried out in rats tested in an inhibitory avoidance paradigm and subjected or not to pre-training (extensive familiarization with the training situation prior to the acquisition trial). Adrenaline injected subcutaneously in a dose of 500 μg/kg facilitated retention performance in rats both subjected or not to pre-training. Naloxone administered SC (400 μg/rat) did not influence retention behavior in rats subjected or not to pre-training, nor did ICV (0.80 ng/rat) administration. Interestingly, the opiate antagonist when injected SC (400 μg/rat) prevented the facilitatory effect exerted by adrenaline in pretrained as well as in not pre-trained rats. However, ICV administration of naloxone (0.80 μg/rat) did not influence the behavioral effects exerted by the bioamine. These data suggested a role of endogenous opioid peptides on the facilitatory effect of adrenaline on memory, possibly independent of novelty factors and thus of the brain β-endorphin system. In addition, our results point to the periphery as the most likely site for such interaction.
eng
closedAccess
Naloxone prevents the facilitatory effect upon retention induced by adrenaline administration in rats
artículo