2024-03-28T20:56:27Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1848582020-12-11T08:59:25Zcom_10261_5062com_10261_5com_10261_123com_10261_8col_10261_5064col_10261_376
Serra-Compte, Albert
Álvarez-Muñoz, Diana
Solé, Montserrat
Cáceres, Núria
Barceló, Damià
Rodríguez-Mozaz, Sara
2019-06-26T09:30:47Z
2019-06-26T09:30:47Z
2019-06
Environmental Research 173: 12-22 (2019)
http://hdl.handle.net/10261/184858
10.1016/j.envres.2019.03.021
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100002809
Antibiotics accumulation in aquatic organisms may be of great concern from an ecological point of view but also from a human perspective, especially when they are accumulated in edible animals like marine mussels. In this work, mussels (Mytilus galloprovincialis) were exposed to sulfamethoxazole antibiotic (SMX) at 10 µg/L during 96 h, followed by 24 h of depuration. The experiment was carried out at summer and winter conditions. SMX showed a bioconcentration factor in mussel of 1.5 L/kg (dry weight) and 69% of the compound was eliminated from the organism in 24 h. The metabolomics approach revealed alterations in amino acids levels (aspartate, phenylalanine, valine and tryptophan) pinpointing disturbances in osmotic regulation and energy metabolism. Besides, the levels of some nucleotides (guanosine and inosine) and a carboxylic acid were also affected. However, SMX exposed mussels did not show any significant alteration in the enzymatic activities related to the xenobiotic metabolism and oxidative stress. Moreover, some of the changes observed in mussel's metabolites suggested alterations in mussel's organoleptic characteristics that can affect its quality as seafood commodity. Overall, our results showed that SMX exposure to marine mussels may have ecological implications by provoking sub-lethal effects to exposed organisms. Nevertheless, no risk for consumers derived from mussel ingestion is expected due to the low bioconcentration capacity of SMX and fast depuration in this seafood type
eng
openAccess
Ecotoxicology
Bioconcentration
Non-targeted metabolomics
Antibiotic pollution
Commercial mussels
Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics
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