2024-03-28T11:32:10Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1710422020-05-26T07:58:43Zcom_10261_54com_10261_1col_10261_307
Crespo-Castrillo, Andrea
Yanguas-Casás, Natalia
Arévalo, María Ángeles
Azcoitia, I.
Barreto, George E.
García-Segura, Luis M.
2018-10-15T11:57:54Z
2018-10-15T11:57:54Z
2018-11
Molecular Neurobiology 55(11): 8651–8667 (2018)
0893-7648
http://hdl.handle.net/10261/171042
10.1007/s12035-018-1008-x
1559-1182
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100010198
http://dx.doi.org/10.13039/100012619
Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actions regulate reactive gliosis. Tibolone is a synthetic steroid that is widely used for the treatment of climacteric symptoms and/or the prevention of osteoporosis. In this study, we have assessed the effect of tibolone on reactive gliosis in the cerebral cortex after a stab wound brain injury in ovariectomized adult female mice. By 7 days after brain injury, tibolone reduced the number of glial fibrillary acidic protein (GFAP) immunoreactive astrocytes, the number of ionized calcium binding adaptor molecule 1 (Iba1) immunoreactive microglia, and the number of microglial cells with a reactive phenotype in comparison to vehicle-injected animals. These effects on gliosis were associated with a reduction in neuronal loss in the proximity to the wound, suggesting that tibolone exerts beneficial homeostatic actions in the cerebral cortex after an acute brain injury.
eng
openAccess
Astrocytes
Microglia
Neuroinflammation
Neuroprotection
Steroid receptors
Brain trauma
The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury
artículo