2024-03-28T09:04:28Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1365872021-12-27T15:55:19Zcom_10261_105com_10261_1col_10261_358
Dragojević, Tanja
Bronzi, Danilo
Varma, Hari M.
Valdés, Claudia P.
Castellví, Clara
Villa, Federica A.
Tosi, Alberto
Justicia, Carles
Zappa, Franco
Durduran, Turgut
2016-09-09T11:54:32Z
2016-09-09T11:54:32Z
2015-07-14
Biomedical Optics Express 6(8): 2865-2876 (2015)
http://hdl.handle.net/10261/136587
10.1364/BOE.6.002865
http://dx.doi.org/10.13039/501100003329
26309751
Laser speckle contrast imaging (LSCI) has emerged as a valuable tool for cerebral blood flow (CBF) imaging. We present a multiexposure laser speckle imaging (MESI) method which uses a high-frame rate acquisition with a negligible inter-frame dead time to mimic multiple exposures in a single-shot acquisition series. Our approach takes advantage of the noise-free readout and high-sensitivity of a complementary metaloxide- semiconductor (CMOS) single-photon avalanche diode (SPAD) array to provide real-time speckle contrast measurement with high temporal resolution and accuracy. To demonstrate its feasibility, we provide comparisons between in vivo measurements with both the standard and the new approach performed on a mouse brain, in identical conditions.
eng
https://www.osapublishing.org/submit/review/copyright_permissions.cfm#posting
openAccess
Avalanche photodiodes
Spectroscopy, speckle
Photon counting
Speckle imaging
High-speed multi-exposure laser speckle contrast imaging with a single-photon counting camera
artículo