2024-03-28T21:09:41Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1137452018-09-19T08:29:27Zcom_10261_31891com_10261_2col_10261_31892
Sánchez-Patán, Fernando
Barroso, Elvira
Wiele, Tom van de
Jiménez-Girón, Ana
Martín-Álvarez, Pedro J.
Moreno-Arribas, M. Victoria
Martínez-Cuesta, M. Carmen
Peláez, Carmen
Requena, Teresa
Bartolomé, Begoña
2015-04-16T09:15:28Z
2015-04-16T09:15:28Z
2015
Food Chemistry 183: 273-282 (2015)
http://hdl.handle.net/10261/113745
10.1016/j.foodchem.2015.03.061
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/100012818
In this study, we have assessed the phenolic metabolism of a cranberry extract by microbiota obtained from the ascending colon and descending colon compartments of a dynamic gastrointestinal simulator (SHIME). For comparison, parallel fermentations with a grape seed extract were carried out. Extracts were used directly without previous intestinal digestion. Among the 60 phenolic compounds targeted, our results confirmed the formation of phenylacetic, phenylpropionic and benzoic acids as well as phenols such as catechol and its derivatives from the action of colonic microbiota on cranberry polyphenols. Benzoic acid (38.4 μg/ml), 4-hydroxy-5-(3′-hydroxyphenyl)-valeric acid (26.2 μg/ml) and phenylacetic acid (19.5 μg/ml) reached the highest concentrations. Under the same conditions, microbial degradation of grape seed polyphenols took place to a lesser extent compared to cranberry polyphenols, which was consistent with the more pronounced antimicrobial effect observed for the grape seed polyphenols, particularly against Bacteroides, Prevotella and Blautia coccoides-Eubacterium rectale.
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Comparative in vitro fermentations of cranberry and grape seed polyphenols with colonic microbiota
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