2024-03-29T02:31:59Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/954842018-08-29T07:59:01Zcom_10261_79com_10261_1col_10261_332
DIGITAL.CSIC
author
Loureiro, Jesús
author
González-Mateo, Guadalupe
author
Jiménez-Heffernan, José A.
author
Selgas, Rafael
author
López Cabrera, Manuel
author
Aguilera-Peralta, Abelardo
2014-04-14T11:14:28Z
2014-04-14T11:14:28Z
2013
International Journal of Nephrology 2013 (2013)
http://hdl.handle.net/10261/95484
10.1155/2013/263285
23476771
Mesothelial-to-mesenchymal transition (MMT) is an autoregulated physiological process of tissue repair that in uncontrolled conditions, such as peritoneal dialysis (PD), can lead to peritoneal fibrosis. The maximum expression of sclerotic peritoneal syndromes (SPS) is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists. The SPS includes a wide range of peritoneal fibrosis that appears progressively and is considered as a reversible process, while EPS does not. EPS is a serious complication of PD characterized by a progressive intra-abdominal inflammatory process that results in bridles and severe fibrous tissue formation which cover and constrict the viscera. Recent studies show that transdifferentiated mesothelial cells isolated from the PD effluent correlate very well with the clinical events such as the number of hemoperitoneum and peritonitis, as well as with PD function (lower ultrafiltration and high Cr-MTC). In addition, in peritoneal biopsies from PD patients, the MMT correlates very well with anatomical changes (fibrosis and angiogenesis). However, the pathway to reach EPS from SPS has not been fully and completely established. Herein, we present important evidence pointing to the MMT that is present in the initial peritoneal fibrosis stages and it is perpetual over time, with at least theoretical possibility that MMT initiated the fibrosing process to reach EPS. © 2013 Jesús Loureiro et al.
eng
openAccess
Are the mesothelial-to-mesenchymal transition, sclerotic peritonitis syndromes, and encapsulating peritoneal sclerosis part of the same process?
artículo
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