2024-03-29T04:46:25Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/670932017-06-02T08:08:45Zcom_10261_54com_10261_1col_10261_307
DIGITAL.CSIC
author
Núñez Molina, Ángel
author
Buño, Washington
2013-02-20T16:14:39Z
2013-02-20T16:14:39Z
1992
Experimental Neurology 115: 266- 270 (1992)
http://hdl.handle.net/10261/67093
10.1016/0014-4886(92)90061-T
The effects of intracellular diffusion of the lidocaine derivative anesthetic QX-314 and of Cs+, which block Na+ and K+ conductances, respectively, were investigated in vivo in rat CA1 and CA3 pyramidal neurons to demonstrate slow Ca2+-related events. QX-314 loading prevented fast Na+ spikes, but slower presumably Ca2+ spikes remained. A slower and a faster duration type of QX-314-resistant spikes were observed. The former had high thresholds, while the latter was activated at moderate depolarized levels. The slower and the faster QX-314-resistant spikes fired at frequencies up to 8/s and 35/s and were 35-60 and 5-10 ms in duration, respectively. With Cs+ loading, pyramidal neurons depolarized and slow, presumably Ca2+, and fast Na+ spikes widened. Fast spikes usually showed a prominent shoulder and a slower repolarization. No differences were observed between drug effects in CA1 and CA3 neurons. In terms of their possible participation in θ rhythm genesis the slow QX-314-resistant events display the correct frequency and duration and can oscillate regeneratively.
eng
closedAccess
Intracellular effects of QX-314 and Cs+ in hippocampal pyramidal neurons in vivo
artículo
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URL
https://digital.csic.es/bitstream/10261/67093/1/accesoRestringido.pdf
File
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application/pdf
accesoRestringido.pdf
URL
https://digital.csic.es/bitstream/10261/67093/5/accesoRestringido.pdf.txt
File
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text/plain
accesoRestringido.pdf.txt