2024-03-28T08:26:17Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/664582016-02-17T12:44:16Zcom_10261_64com_10261_1col_10261_317
DIGITAL.CSIC
author
Assassi, S.
author
Radstake, T. R.
author
Mayes, Maureen D.
author
Martín, J.
2013-02-08T20:04:43Z
2013-02-08T20:04:43Z
2013-01-11
BMC Medicine 11(1) : 9- (2013)
http://hdl.handle.net/10261/66458
Abstract Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several genes have been recently linked to various systemic sclerosis disease manifestations. Furthermore, inclusion of genetic studies in design and analysis of drug trials could lead to development of genetic biomarkers that predict treatment response. Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis.
eng
openAccess
Genetics of scleroderma: implications for personalized medicine?
artículo
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