2024-03-28T23:42:11Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/46992020-05-29T09:51:39Zcom_10261_79com_10261_1col_10261_332
DIGITAL.CSIC
author
Manjón, Cristina
author
Sánchez-Herrero, Ernesto
author
Suzanne, Magali
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid
funder
Fundación Ramón Areces
funder
Ministerio de Educación y Ciencia (España)
2008-05-30T12:41:27Z
2008-05-30T12:41:27Z
2006-12-03
Nature Cell Biology 9, 57 - 63 (2006)
1465-7392
http://hdl.handle.net/10261/4699
1476-4679
http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/100008054http://dx.doi.org/10.13039/100012818
Morphogens are secreted signalling molecules that govern many developmental processes1. In the Drosophila wing disc, the transforming growth factor (TGF) homologue Decapentaplegic (Dpp) forms a smooth gradient and specifies cell fate by conferring a defined value of morphogen activity. Thus, neighbouring cells have similar amounts of Dpp protein, and if a sharp discontinuity in Dpp activity is generated between these cells, Jun kinase (JNK)-dependent apoptosis is triggered to restore graded positional information2, 3. To date, it has been assumed that this apoptotic process is only activated when normal signalling is distorted. However, we now show that a similar process occurs during normal development: rupture in Dpp activity occurs during normal segmentation of the distal legs of Drosophila. This sharp boundary of Dpp signalling, independently of the absolute level of Dpp activity, induces a JNK—reaper-dependent apoptosis required for the morphogenesis of a particular structure of the leg, the joint. Our results show that Dpp could induce a developmental programme not only in a concentration dependent manner, but also by the creation of a sharp boundary of Dpp activity. Furthermore, the same process could be used either to restore a normal pattern in response to artificial disturbance or to direct a morphogenetic process.
eng
openAccess
Drosophila
Decapentaplegic
Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis
artículo
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