2024-03-28T09:56:21Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/276242023-01-30T08:55:21Zcom_10261_5062com_10261_5col_10261_5064
DIGITAL.CSIC
author
Kogevinas, Manolis
author
Villanueva, Cristina M.
author
Font-Ribera, Laia
author
Liviac, Danae
author
Bustamante, Mariona
author
Espinoza, Felicidad
author
Nieuwenhuijsen, Mark J.
author
Espinosa, Aina
author
Fernández Ramón, M. Pilar
author
DeMarini, David M.
author
Grimalt, Joan O.
author
Grummt, Tamara
author
Marcos, Ricard
2010-09-14T11:04:58Z
2010-09-14T11:04:58Z
2010-09-12
Environmental Health Perspectives (EHP): (2010)
0091-6765
http://hdl.handle.net/10261/27624
10.1289/ehp.1001959
20833606
[BACKGROUND]: Exposure to disinfection by-products (DBPs) in drinking water has
been associated with cancer risk. A recent study found an increased bladder cancer risk
among subjects attending swimming pools relative to those not attending.
[OBJECTIVES]: To evaluate whether swimming in pools is associated with biomarkers
of genotoxicity.
[METHODS]: We collected blood, urine, and exhaled air samples from 49 non-smoking
adult volunteers before and after they swam for 40 min in an indoor chlorinated pool.
We estimated associations between the concentrations of four trihalomethanes in
exhaled breath and changes in the following biomarkers: micronuclei and DNA damage
(comet assay) in peripheral blood lymphocytes before and 1 h after swimming, urine
mutagenicity (Ames assay) before and 2 h after swimming, and micronuclei in
exfoliated urothelial cells before and 2 weeks after swimming. We also estimated
associations and interactions with polymorphisms in genes related to DNA repair or
DBP metabolism.
[RESULTS]: After swimming, the total concentration of the four trihalomethanes in
exhaled breath was seven times higher than before swimming. The change in the
frequency of micronucleated lymphocytes after swimming increased in association with
exhaled concentrations of the brominated trihalomethanes (p = 0.03 for CHCl2Br, p =
0.05 for CHClBr2, p = 0.01 for CHBr3) but not chloroform. Swimming was not
associated with DNA damage detectable by the comet assay. Urine mutagenicity
increased significantly after swimming in association with the concentration of exhaled
CHBr3 (p = 0.004). No significant associations with changes in micronucleated
urothelial cells were observed.
[CONCLUSIONS]: Our findings support potential genotoxic effects of exposure to
DBPs from swimming pools. The positive health effects gained by swimming could be
increased by reducing the potential health risks of pool water.
eng
openAccess
Swimming pools
Water
Chlorination
Disinfection by-products
Cancer
Genotoxicity
Mutagenicity
Genetics
Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools
artículo
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