2024-03-28T10:52:16Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1754802019-02-08T01:56:43Zcom_10261_14com_10261_8col_10261_393
DIGITAL.CSIC
author
Volland, Moritz
author
Hampel, Miriam
author
Katsumiti, Alberto
author
Yeste, María Pilar
author
Gatica, José Manuel
author
Cajaraville, Miren
author
Blasco, Julián
2019-02-07T11:27:14Z
2019-02-07T11:27:14Z
2016-09
30th ESCPB Congress (2016)
http://hdl.handle.net/10261/175480
Copper oxide nanoparticles (CuO NPs) are increasingly investigated, developed and manufactured for a wide and promising array of commercial and industrial products. Their increased production use and disposal will eventually lead to their increased release into the aquatic environment and potentially affect non-target organisms within. Although CuO NPs have been identified to be potentially cytotoxic, little is known about their behaviour in the marine environment and its potential influence on their cytotoxicity. We studied aggregation and dissolution kinetics of two commercially available bare copper oxide nanoparticles with nominal similar mean sizes (~ 40 nm), but distinct synthesis processes (wet chemistry and combustion synthesis) in various environmental and experimental relevant conditions. In addition cytotoxicity and DNA damage, as well as gene expression of oxidative stress, inflammatory response, DNA damage repair and cell death mediator markers were studied in Ruditapes philippinarum haemocytes after 24 h in vitro exposure and compared with sub-micron CuO (~ 500 nm) and water soluble Cu treated cells. Our results indicate that aggregating behaviour largely influences the toxicity of CuO NPs by influencing their susceptibility to ion leaching from the particle/aggregate surface. Gene expression analysis identified highly similar modes of action for all tested particulate and ionic Cu forms, further substantiating that nano and bulk CuO toxicity might largely be driven by ionic Cu. In addition our work highlights various differences in the behaviour of CuO NPs in environmental and culture conditions that need consideration when extrapolating results from in vitro to natural (or environmental) conditions.
eng
closedAccess
Cytotoxicity of copper oxide nanoparticles on haemocytes of the marine bivalve Ruditapes philippinarum: an in vitro approach
comunicación de congreso
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URL
https://digital.csic.es/bitstream/10261/175480/1/accesoRestringido.pdf
File
MD5
ebc0238b6993fbe94c581f365dfc5974
60661
application/pdf
accesoRestringido.pdf