2024-03-28T23:11:53Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1673442020-12-13T09:03:48Zcom_10261_56com_10261_3col_10261_309
DIGITAL.CSIC
author
Santos-Coquillat, A.
author
Martínez-Campos, Enrique
author
Mohedano, M.
author
Martínez-Corriá, R.
author
Ramos, Viviana
author
Arrabal, R.
author
Matykina, E.
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Comunidad de Madrid
funder
European Commission
funder
Consejo Superior de Investigaciones Científicas (España)
2018-07-04T08:19:49Z
2018-07-04T08:19:49Z
2018
Surface and Coatings Technology 347: 358-368 (2018)
http://hdl.handle.net/10261/167344
10.1016/j.surfcoat.2018.04.051
http://dx.doi.org/10.13039/501100003339http://dx.doi.org/10.13039/501100000780http://dx.doi.org/10.13039/501100010198http://dx.doi.org/10.13039/100012818
This work investigated the capacity of plasma electrolytic oxidation coatings on titanium for biological regulation via controlled surface composition and morphology in order to improve osseointegration and implant fixation. PEO coatings with relatively high Ca/P ratios of ~2.0 and ~4.0 were designed, characterized and evaluated in vitro, focusing on murine osteoblast and osteoclast activities in order to reflect the equilibrium between bone synthesis and resorption. The coating with elevated anatase content and surface Ca/P ratio of ~2.0 disclosed a diminished osteoclast activity and adequate osteoblast differentiation, favoring an augmented bone matrix synthesis over resorption processes. The coating with Ca/P ratio of 4.0 and reduced pore population density enabled greater osteoclastic resorptive activity. Additionally, commercial mechanised dental implants were PEO-coated and placed in an adult pig for 8 weeks in order to test their biocompatibility and implant integration in a preliminary in vivo approach. Both coatings revealed positive behaviour, strong bone matrix deposition at the implant-tissue interface and higher mean BIC values than Ti CP, with no appreciable differences between the two coatings.
eng
closedAccess
Osteoblast
Plasma electrolytic oxidation
Osteoclast
Titanium
Dental implant
In vitro and in vivo evaluation of PEO-modified titanium for bone implant applications
artículo
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URL
https://digital.csic.es/bitstream/10261/167344/1/accesoRestringido.pdf
File
MD5
42637ae8545636bc41605c1740a9a84e
15753
application/pdf
accesoRestringido.pdf