2024-03-29T04:48:35Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1576862017-12-18T14:00:03Zcom_10261_39com_10261_1com_10261_54col_10261_292col_10261_307
DIGITAL.CSIC
author
Crespo-Sanjuán, Jesús
author
Calvo-Rodríguez, María
author
Sánchez, Diego
author
Bajo-Grañeras, Raquel
author
García-Centeno, Rosa
author
Bustamante, Rosa
author
Garrote, José Antonio
funder
Junta de Castilla y León
2017-11-24T08:01:56Z
2017-11-24T08:01:56Z
2015
Laboratory Medicine 46(2): 123-135 (2015)
http://hdl.handle.net/10261/157686
10.1309/LMZJJU6BC86WUDHW
http://dx.doi.org/10.13039/501100014180
[Objectives]: To detect whether signs of oxidative stress appear at early stages of colorectal adenocarcinoma (CRC), particularly in the polyp stage. We also aimed to evaluate the specific entities myeloperoxidase (MPO) and oxidized low-density lipoprotein (oxLDL) as novel markers of oxidation in the plasma of patients with CRC and to study the relationship between oxidative status in plasma and patient survival. [Methods]: We assayed serum or plasma specimens from healthy control subjects (n = 14), from patients with intestinal polyps (n = 39), and from patients with CRC (n = 128) to calculate the modified oxidative balance score (MOBS) using several serum markers (β-carotene, lycopene, vitamin A, vitamin E, MPO, and oxLDL). We also assayed the levels of C-reactive protein (CRP) and obtained lipid profiles. Finally, we studied the survival of patients in relationship to oxidative status (antioxidants and pro-oxidants) and inflammation markers, and added theses data to the lipid profile for each patient. [Results]: Oxidative stress levels increased as disease stage advanced. This increase was detected early in the polyp stage, before polyps progressed to cancer, and could be measured by the increase of such new markers as MPO and oxLDL, the decrease in antioxidants, and the MOBS value. Higher levels of oxidation correlated with lower survival. [Conclusion]: The oxidation process, which can cause mutations leading to CRC, begins development in the polyp stage. This process may be detected early by monitoring serum markers such as MPO and oxLDL.
eng
closedAccess
Oxidative stress
Cancer biomarkers
Antioxidants
Myeloperoxidase
LDL oxidized
Colorectal cancer
Early detection of high oxidative activity in patients with adenomatous intestinal polyps and colorectal adenocarcinoma: Myeloperoxidase and oxidized low-density lipoprotein in serum as new markers of oxidative stress in colorectal cancer
artículo
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URL
https://digital.csic.es/bitstream/10261/157686/1/accesoRestringido.pdf
File
MD5
42637ae8545636bc41605c1740a9a84e
15753
application/pdf
accesoRestringido.pdf