2024-03-28T14:45:18Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1570412017-12-18T14:33:16Zcom_10261_44755com_10261_1col_10261_44757
DIGITAL.CSIC
author
Bolaños, Juan P.
author
Cadenas, Enrique
author
Duchen, Michael R.
author
Hampton, Mark B.
author
Mann, Giovanni E.
author
Murphy, Michael P.
funder
Biotechnology and Biological Sciences Research Council (UK)
funder
Parkinson's Disease Society (UK)
funder
British Heart Foundation
funder
National Institutes of Health (US)
2017-11-07T08:14:51Z
2017-11-07T08:14:51Z
2016
Free Radical Biology and Medicine 100: 1-4 (2016)
http://hdl.handle.net/10261/157041
10.1016/j.freeradbiomed.2016.08.004
http://dx.doi.org/10.13039/501100000268http://dx.doi.org/10.13039/501100000274http://dx.doi.org/10.13039/100000002
Mitochondria are functional entities that harbor the energy-conservation machinery that supports cell function through the coordination of mitochondrion-derived molecules involved in the regulation of cell signaling and transcription. Conversely, mitochondria are targets of an ever-increasing number of signaling pathways and their activity is also modulated by several transcription factors. The cell's energy-redox homeostasis is primarily a function of mitochondrial oxidative phosphorylation and the formation of O2.–/H2O2. Notably, other mitochondrion-driven processes contribute to cellular homeostasis, such as mitochondrial biogenesis and dynamics, mitochondrial quality control (autophagy and mitophagy), mitochondrial proteostasis and the role of the mitochondrial unfolded protein response (UPRmt), and redox signaling in the homeostatic control of mitochondrial function. This Free Radical Biology & Medicine special issue on Mitochondrial Redox Signaling in Health and Disease covers some aspects of the myriad of processes embraced by mitochondrial biology and physiology, provides mechanistic insights linking mitochondrial function with cell function, and recognizes mitochondrial function as an amenable therapeutic target.
eng
openAccess
Introduction to special issue on mitochondrial redox signaling in health and disease
artículo
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URL
https://digital.csic.es/bitstream/10261/157041/1/intoducionredoxsignaling.pdf
File
MD5
2584d0750bbee69c4856bad9371ce6ab
275233
application/pdf
intoducionredoxsignaling.pdf