2024-03-29T09:46:03Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1565022019-09-27T12:02:54Zcom_10261_84com_10261_5col_10261_337
DIGITAL.CSIC
author
Marbán Calzón, Gregorio
author
Ramírez Montoya, Luis Adrián
author
García Álvarez, Héctor
author
Menéndez Díaz, José Ángel
author
Arenillas de la Puente, Ana
author
Montes Morán, Miguel Ángel
funder
Ministerio de Economía y Competitividad (España)
funder
Principado de Asturias
2017-10-20T12:09:00Z
2017-10-20T12:09:00Z
2017-09-23
Journal of Colloid and Interface Science 511: 27-38 (2018)
0021-9797
http://hdl.handle.net/10261/156502
10.1016/j.jcis.2017.09.091
1095-7103
http://dx.doi.org/10.13039/501100003329http://dx.doi.org/10.13039/100011941
The adsorption of cytochrome c in water onto organic and carbon xerogels with narrow pore size distributions has been studied by carrying out transient and equilibrium batch adsorption experiments. It was found that equilibrium adsorption exhibits a quasi-Langmuirian behavior (a g coefficient in the Redlich-Peterson isotherms of over 0.95) involving the formation of a monolayer of cyt c with a depth of ∼4 nm on the surface of all xerogels for a packing density of the protein inside the pores of 0.29 g cm–3. A load-dependent surface diffusion model (LDSDM) has been developed and numerically solved to fit the experimental kinetic adsorption curves. The results of the LDSDM show better fittings than the standard homogeneous surface diffusion model. The value of the external mass transfer coefficient obtained by numerical optimization confirms that the process is controlled by the intraparticle surface diffusion of cyt c. The surface diffusion coefficients decrease with increasing protein load down to zero for the maximum possible load. The decrease is steeper in the case of the xerogels with the smallest average pore diameter (∼15 nm), the limit at which the zero-load diffusion coefficient of cyt c also begins to be negatively affected by interactions with the opposite wall of the pore.
eng
openAccess
Adsorption
Kinetics
Surface diffusion
Protein
Mesoporous
Load-dependent surface diffusion model for analyzing the kinetics of protein adsorption onto mesoporous materials
artículo
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URL
https://digital.csic.es/bitstream/10261/156502/1/Load-dependent_Marban_JCIS.pdf
File
MD5
bfd7add26572f7fddaa2b22c20fc4fa8
583973
application/pdf
Load-dependent_Marban_JCIS.pdf