2024-03-28T14:09:14Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1538062017-08-04T00:54:50Zcom_10261_11773com_10261_1col_10261_11778
DIGITAL.CSIC
author
Rojas, A. M.
author
Valencia, Alfonso
2017-08-03T07:05:45Z
2017-08-03T07:05:45Z
2014
Ras Superfamily Small G Proteins: Biology and Mechanisms 1: 3-24 (2014)
978-3-7091-1806-1
http://hdl.handle.net/10261/153806
10.1007/978-3-7091-1806-1_1
The Ras superfamily of small GTPases illustrates a large functional diversification in the context of a preserved structural framework and a prototypic GTP-binding site. The Ras superfamily of small GTP-binding proteins is essential to regulate the cellular organization and signaling in cells. Members of this superfamily contain a structurally and mechanistically preserved GTP-binding core, with considerable functional and sequence divergence. In this chapter we review the evolutionary structure of the superfamily at the organism and sequence level, presenting a representative tree that reflects the history of the Ras superfamily including crucial evolutionary time points and detailed trees for the Rho, Ras, Rab, Arf, and Ran families. Based on this information we discuss some of the complex relationships between the evolution of proteins and the acquisition of distinctive cellular functions.
eng
closedAccess
Ras phylogeny
Small GTPases
GTP-binding
Multiple sequence alignments
Evolution of the Ras Superfamily of GTPases
capĂtulo de libro
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URL
https://digital.csic.es/bitstream/10261/153806/1/accesoRestringido.pdf
File
MD5
42637ae8545636bc41605c1740a9a84e
15753
application/pdf
accesoRestringido.pdf