2024-03-19T03:38:33Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/998962018-05-24T14:20:39Zcom_10261_31891com_10261_2col_10261_31892
00925njm 22002777a 4500
dc
Jiménez-Girón, Ana
author
Queipo-Ortuño, María Isabel
author
Muñoz-González, Irene
author
Sánchez-Patán, Fernando
author
Monagas Juan, María Josefina
author
Martín-Álvarez, Pedro J.
author
Tinahones, Francisco J.
author
Andrés-Lacueva, Cristina
author
Bartolomé, Begoña
author
Moreno-Arribas, M. Victoria
author
2013
The analysis of microbial phenolic metabolites in fecal samples from in vivo studies is crucial to understanding the potential modulatory effects derived from polyphenol consumption and its overall health effects, particularly at the gut level. In this study, the composition of microbial phenolic metabolites in human feces collected after regular consumption of either red wine, dealcoholized red wine, or gin was analyzed by UPLC-ESI-MS/MS. Red wine interventions produce a change in the content of eight phenolic acids, which are probably derived from the catabolism of flavan-3-ols and anthocyanins, the main flavonoids in red wine. Moreover, alcohol seemed not to influence the formation of phenolic metabolites by the gut microbiota. A principal component analysis revealed large interindividual differences in the formation of microbial metabolites after each red wine polyphenol intervention, but not after the gin intervention, indicating differences in the gut microbial composition among subjects. © 2013 American Chemical Society.
Journal of Agricultural and Food Chemistry 61(16): 3909-3915 (2013)
http://hdl.handle.net/10261/99896
10.1021/jf400678d
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/100012818
Feces
UPLC-ESI-MS/MS
Microbial metabolites
Gut microbiota
Red wine polyphenols
Comparative study of microbial-derived phenolic metabolites in human feces after intake of gin, red wine, and dealcoholized red wine