2024-03-29T00:06:32Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/817562020-04-07T10:25:26Zcom_10261_22com_10261_1com_10261_46com_10261_3com_10261_105col_10261_275col_10261_299col_10261_358
00925njm 22002777a 4500
dc
Rodríguez, Elisenda
author
Roig Serra, Anna
author
Molins, Elies
author
Arús, Carles
author
Cabañas, Miquel E.
author
Sanfeliu, Coral
author
Cerdán, Sebastián
author
García-Martín, María L.
author
2007
A new iron-based T 1 contrast agent consisting of a complex of iron ions coordinated to phosphate and amine ligands (Fe(phos) in short) has been characterized by spectroscopic and magnetic measurements. NMR relaxation studies showed r 1 values to be dependent on the phosphate salt concentration, K2HPO4, present in the medium. r 1 reaches a maximum value of 2.5 mM-1 s-1 for measurements carried out at 7 T and 298 K. 31P MRS, Mössbauer spectroscopy and magnetic measurements of Fe(phos) solutions suggest paramagnetic Fe3+ ions present in the studied iron-phosphate complex. In vitro and in vivo toxicity experiments with C6 cells and CD1 mice, respectively, demonstrated lack of toxicity for Fe(phos) at the highest dose tested in the MRI experiments (12 mM iron for C6 cells and 0.32 mmol iron/kg for mice). Finally, T 1 weighted images of brain tumours in mice have shown positive contrast enhancement of Fe(phos) for tumour afflicted regions in the brain. © 2007 ESMRMB.
Magnetic Resonance Materials in Physics, Biology, and Medicine 20(1): 27-37 (2007)
http://hdl.handle.net/10261/81756
10.1007/s10334-006-0066-7
http://dx.doi.org/10.13039/501100006280
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100001871
An iron-based T 1 contrast agent made of iron-phosphate complexes: In vitro and in vivo studies