2024-03-29T06:41:03Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/717562021-12-27T16:22:40Zcom_10261_86com_10261_1col_10261_339
00925njm 22002777a 4500
dc
Batlle, R.
author
Barderas, Rodrigo
author
Bonilla, Félix
author
Casal, J. Ignacio
author
García de Herreros, Antonio
author
2013
The Snail1 transcriptional repressor plays a key role in triggering epithelial-to-mesenchymal transition. Although Snail1 is widely expressed in early development, in adult animals it is limited to a subset of mesenchymal cells where it has a largely unknown function. Using a mouse model with inducible depletion of Snail1, here we demonstrate that Snail1 is required to maintain mesenchymal stem cells (MSCs). This effect is associated to the responsiveness to transforming growth factor (TGF)-β1 that shows a strong Snail1 dependence. Snail1 depletion in conditional knockout adult animals causes a significant decrease in the number of bone marrow-derived MSCs. In culture, Snail1-deficient MSCs prematurely differentiate to osteoblasts or adipocytes and, in contrast to controls, are resistant to the TGF-β1-induced differentiation block. These results demonstrate a new role for Snail1 in TGF-β response and MSC maintenance
Oncogene 32(28): 3381-3389 (2013) advance online publication
0950-9232
http://hdl.handle.net/10261/71756
10.1038/onc.2012.342
1476-5594
http://dx.doi.org/10.13039/501100002704
http://dx.doi.org/10.13039/501100006280
http://dx.doi.org/10.13039/100008666
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100002809
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100000780
22869142
Snail1
Mesenchymal stem cells
TGF-β
AKT
Snail1 controls TGFB responsiveness and differentiation of mesenchymal stem cells