2024-03-29T05:59:16Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/592322018-10-18T09:59:55Zcom_10261_70com_10261_2col_10261_323
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Martínez Gómez, D.
author
Gómez Martínez, Sonia
author
Ruiz, Jonatan R.
author
Díaz, L. E.
author
Ortega, F. B.
author
Widhalm, Kurt
author
Cuenca García, María Luisa
author
Manios, Yannis
author
De Vriendt, T.
author
Molnár, Dénes
author
Huybrechts, Inge
author
Breidenassel, C.
author
Gottrand, Frederic
author
Plada, M.
author
Moreno, Sara
author
Ferrari, Marika
author
Moreno, Luis A.
author
Sjöström, Michael
author
Marcos, Ascensión
author
2012
Objective: Atherogenesis involves an inflammatory process that occurs early in life even though clinical symptoms are not observed until adulthood. Two important protective factors for low-grade inflammation may be physical activity (PA) and fitness. We examined the independent associations of objective and subjective measurements of PA and fitness with low-grade inflammation in European adolescents. Methods: A total of 1045 adolescents, aged from 12.5 to 17.5 years old from 10 European cities, were selected from the HELENA-Cross-Sectional Study. Objectively-measured and self-reported PA variables were obtained by accelerometry and the International PA Questionnaire for Adolescents, respectively. Overall, cardiorespiratory, muscular and motor fitness variables were assessed by standardized field-based fitness tests and the International Fitness Scale. C-reactive protein (CRP), complement factors 3 (C3) and 4 (C4), interleukin-6 and TNF-α inflammatory markers were measured. Results: Objectively-measured vigorous PA was inversely associated with C3 (β= -0.094, P= 0.021) but it did not remain significant after any objective fitness indicator was included in the model. Other objectively measured or self-reported assessments of PA were not significantly associated with inflammatory markers. All objective measures of fitness were inversely associated with CRP, C3 and C4, whereas only self-reported motor fitness remained significantly associated with C3, C4 and TNF-α. All these observations were independent of age, sex, city and body mass index or waist circumference. Conclusion: High PA in adolescence may play an indirect role on lessening low-grade inflammation through improvements in fitness. © 2011 Elsevier Ireland Ltd.
Atherosclerosis 221: 260- 267 (2012)
http://hdl.handle.net/10261/59232
10.1016/j.atherosclerosis.2011.12.032
Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents: The HELENA Study