2024-03-29T11:26:36Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/2005632021-12-27T15:45:27Zcom_10261_54com_10261_1col_10261_307
00925njm 22002777a 4500
dc
Díez-García, Andrea
author
Barros-Zulaica, Natali
author
Núñez Molina, Ángel
author
Buño, Washington
author
Fernández de Sevilla, D.
author
2017-02
According to Hebb's original hypothesis (Hebb, 1949), synapses are reinforced when presynaptic activity triggers postsynaptic firing, resulting in long-term potentiation (LTP) of synaptic efficacy. Long-term depression (LTD) is a use-dependent decrease in synaptic strength that is thought to be due to synaptic input causing a weak postsynaptic effect. Although the mechanisms that mediate long-term synaptic plasticity have been investigated for at least three decades not all question have as yet been answered. Therefore, we aimed at determining the mechanisms that generate LTP or LTD with the simplest possible protocol. Low-frequency stimulation of basal dendrite inputs in Layer 5 pyramidal neurons of the rat barrel cortex induces LTP. This stimulation triggered an EPSP, an action potential (AP) burst, and a Ca2+ spike. The same stimulation induced LTD following manipulations that reduced the Ca2+ spike and Ca2+ signal or the AP burst. Low-frequency whisker deflections induced similar bidirectional plasticity of action potential evoked responses in anesthetized rats. These results suggest that both in vitro and in vivo similar mechanisms regulate the balance between LTP and LTD. This simple induction form of bidirectional hebbian plasticity could be present in the natural conditions to regulate the detection, flow, and storage of sensorimotor information.
Frontiers in Cellular Neuroscience 11(8): 1-15 (2017)
http://hdl.handle.net/10261/200563
10.3389/fncel.2017.00008
1662-5102
http://dx.doi.org/10.13039/501100006280
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/100012818
http://dx.doi.org/10.13039/501100004593
28203145
Ca2+spikes
NMDARs
L-type VGCC
Dentritic excitabilty
STDP
Bidirectional hebbian plasticity induced by low-frequency stimulation in basal dendrites of rat barrel cortex layer 5 pyramidal neurons