2024-03-29T15:45:29Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1953562021-12-27T15:51:27Zcom_10261_5063com_10261_5com_10261_47com_10261_8col_10261_5066col_10261_300
00925njm 22002777a 4500
dc
Hereu, Mercè
author
Ramos-Romero, Sara
author
Marín-Valls, Roser
author
Amézqueta, Susana
author
Miralles-Pérez, Bernat
author
Romeu, Marta
author
Méndez, Lucía
author
Medina, Isabel
author
Torres, Josep Lluís
author
2019-10-31
Some functional food components may help maintain homeostasis by promoting balanced gut microbiota. Here, we explore the possible complementary effects of d-fagomine and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA 1:1) on putatively beneficial gut bacterial strains. Male Sprague–Dawley rats were supplemented with d-fagomine, ω-3 PUFAs, or both, for 23 weeks. Bacterial subgroups were evaluated in fecal DNA by quantitative real-time polymerase chain reaction (qRT-PCR) and short-chain fatty acids were determined by gas chromatography. We found that the populations of the genus Prevotella remained stable over time in animals supplemented with d-fagomine, independently of ω-3 PUFA supplementation. Animals in these groups gained less weight than controls and rats given only ω-3 PUFAs. d-Fagomine supplementation together with ω-3 PUFAs maintained the relative populations of Bacteroides. ω-3 PUFAs alone or combined with d-fagomine reduced the amount of acetic acid and total short-chain fatty acids in feces. The plasma levels of pro-inflammatory arachidonic acid derived metabolites, triglycerides and cholesterol were lower in both groups supplemented with ω-3 PUFAs. The d-fagomine and ω-3 PUFAs combination provided the functional benefits of each supplement. Notably, it helped stabilize populations of Prevotella in the rat intestinal tract while reducing weight gain and providing the anti-inflammatory and cardiovascular benefits of ω-3 PUFAs.
Nutrients 11(11): 2606 (2019)
http://hdl.handle.net/10261/195356
10.3390/nu11112606
2072-6643
http://dx.doi.org/10.13039/501100011033
http://dx.doi.org/10.13039/501100003329
31683529
Weight
gut microbiota
Prevotella
Bacteroides
D-fagomine
iminosugar
iminocyclitol
ω-3 PUFAs
Combined buckwheat d-Fagomine and fish Omega-3 PUFAs stabilize the populations of gut prevotella and bacteroides while reducing weight gain in rats