2024-03-29T05:06:14Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1538702017-08-08T00:53:37Zcom_10261_11773com_10261_1col_10261_11776
00925njm 22002777a 4500
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Arcas, Aída
author
Fernández-Capetillo, Óscar
author
Cases, Ildefonso
author
Rojas, A. M.
author
2014-09
The DNA Damage response is a crucial signaling network that preserves the integrity of the genome. To understand
how these elements have been assembled together in humans, we performed comparative genomic analyses in selected species to trace back their emergence using systematic phylogenetic analyses and estimated gene ages. The
emergence of the contribution of post-translational modifications to the complex regulation of DDR was also investigated. This is the first time a systematic analysis has focused on the evolution of DDR sub-networks as a whole. Our
results indicate that a DDR core, mostly constructed around metabolic activities, appeared soon after the emergence of
eukaryotes, and that additional regulatory capacities appeared later through complex evolutionary process. Potential
key post-translational modifications were also in place then, with interacting pairs preferentially appearing at the same
evolutionary time, although modifications often led to the subsequent acquisition of new targets afterwards. We also
found extensive gene loss in essential modules of the regulatory network in fungi, plants and arthropods, important for
their validation as model organisms for DDR studies.
XII Symposium on Bioinformatics (2014)
http://hdl.handle.net/10261/153870
Emergence of the human DNA Damage Response Network