2024-03-29T06:50:34Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1325932022-12-21T08:33:43Zcom_10261_36com_10261_4col_10261_289
00925njm 22002777a 4500
dc
Ruz MartÃnez, José Jaime
author
Tamayo de Miguel, Francisco Javier
author
Pini, Valerio
author
Kosaka, Priscila M.
author
Calleja, Montserrat
author
2014-08-13
There is an emerging need of nanotools able to quantify the mechanical properties of single biological entities. A promising approach is the measurement of the shifts of the resonant frequencies of ultrathin cantilevers induced by the adsorption of the studied biological systems. Here, we present a detailed theoretical analysis to calculate the resonance frequency shift induced by the mechanical stiffness of viral nanotubes. The model accounts for the high surface-to-volume ratio featured by single biological entities, the shape anisotropy and the interfacial adhesion. The model is applied to the case in which tobacco mosaic virus is randomly delivered to a silicon nitride cantilever. The theoretical framework opens the door to a novel paradigm for biological spectrometry as well as for measuring the Young's modulus of biological systems with minimal strains.
Scientific Reports 4: 6051 (2014)
http://hdl.handle.net/10261/132593
10.1038/srep06051
http://dx.doi.org/10.13039/501100000781
http://dx.doi.org/10.13039/501100003329
25116478
Physics of nanomechanical spectrometry of viruses