2024-03-29T02:30:40Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1300872020-07-28T06:57:43Zcom_10261_5063com_10261_5col_10261_5066
00925njm 22002777a 4500
dc
Castangia, Ines
author
Manca, Maria Letizia
author
Caddeo, Carla
author
Maxia, Andrea
author
Murgia, Sergio
author
Pons Pons, Ramon
author
Demurtas, Davide
author
Pando, Daniel
author
Falconieri, Danilo
author
Péris, José Esteban
author
Fadda, Anna Maria
author
Manconi, Maria
author
2015-08-01
The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the oil to the skin.S. insularis essential oil was obtained by steam distillation, and was predominantly composed of terpenes, the most abundant being β-phellandrene (22.6%), myrcene (11.4%) and curcumenes (12.1%). Vesicles were prepared using phosphatidylcholine, and ethylene or propylene glycol were added to the water phase (10% (v/v)) to improve vesicle performances as delivery systems. Vesicles were deeply characterized by light scattering, cryogenic transmission electron microscopy and small/wide-angle X-ray scattering, the results showing polyhedral, faceted, unilamellar vesicles of ~115. nm in size. The presence of the glycols improved vesicle stability under accelerated ageing conditions, without changes in size or migration phenomena (e.g. sedimentation and creaming). Confocal laser scanning microscopy images of pig skin treated with S. insularis formulations displayed a penetration ability of PEVs greater than that of control liposomes. Moreover, all formulations showed a marked in vitro biocompatibility in human keratinocytes.These findings suggest that the nanoformulation may be of value in enhancing the delivery of S. insularis essential oil to the skin, where it can exert its biological activities.
Colloids and Surfaces - B - Biointerfaces
http://hdl.handle.net/10261/130087
10.1016/j.colsurfb.2015.05.025
http://dx.doi.org/10.13039/501100003329
Ethylene/propylene glycol
Human keratinocytes
Phospholipid vesicles
Pig skin
Santolina insularis essential oil
Terpenes
Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin