2024-03-28T11:28:58Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1264662019-10-10T13:35:24Zcom_10261_64com_10261_1col_10261_317
00925njm 22002777a 4500
dc
Ortiz, Miguel A.
author
Núñez, Concepción
author
Ordóñez, David
author
Álvarez-Cermeño, José Carlos
author
Martínez-Rodriguez, José E.
author
Sánchez, Antonio J.
author
Arroyo, Rafael
author
Izquierdo, Guillermo
author
Malhotra, Sunny
author
Montalbán, Xavier
author
García-Merino, Antonio
author
Munteis, Elvira
author
Alcina, Antonio
author
Comabella, Manuel
author
Matesanz, F.
author
Villar, Luisa M.
author
Urcelay, Elena
author
2015-08-14
Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results.
Objectives
In an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities.
Results and Conclusion
Overall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0.25, OR (95% CI) = 1.07 (0.95–1.19)], even after stratification by gender and the HLA-DRB1*15:01 risk allele.
PLoS ONE
http://hdl.handle.net/10261/126466
10.1371/journal.pone.0134414
1932-6203
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100011011
26274821
Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta- Analysis