2024-03-29T15:38:17Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1163632021-09-06T10:48:34Zcom_10261_68com_10261_2col_10261_321
00925njm 22002777a 4500
dc
Buil-Cosiales, Pilar
author
Zazpe, Itzíar
author
Toledo, Estefanía
author
Corella, Dolores
author
Salas-Salvadó, Jordi
author
Díez-Espino, Javier
author
Ros, Emilio
author
Navajas, Joaquín F.C.
author
Santos-Lozano, José Manuel
author
Arós, Fernando
author
Fiol, Miquel
author
Castañer, Olga
author
Serra-Majem, Lluís
author
Pintó, Xavier
author
Lamuela-Raventós, Rosa M.
author
Marti, Amelia
author
Basterra-Gortari, F. Javier
author
Sorlí, José V.
author
Verdú-Rotellar, José M.
author
Basora, Josep
author
Ruiz-Gutiérrez, Valentina
author
Estruch, Ramón
author
Martínez-González, Miguel Ángel
author
2014
Background: Few observational studies have examined the effect of dietary fiber intake and fruit and vegetable consumption on total mortality and have reported inconsistent results. All of the studies have been conducted in the general population and typically used only a single assessment of diet. Objective: We investigated the association of fiber intake and whole-grain, fruit, and vegetable consumption with all-cause mortality in a Mediterranean cohort of elderly adults at high cardiovascular disease (CVD) risk by using repeated measurements of dietary information and taking into account the effect of a dietary intervention. Design: We followed up 7216 men (55-75 y old) and women (60-75 y old) at high CVD risk in the Prevención con Dieta Mediterránea (PREDIMED) trial for a mean of 5.9 y. Data were analyzed as an observational cohort. Participants were initially free of CVD. A 137-item validated food-frequency questionnaire administered by dietitians was repeated annually to assess dietary exposures (fiber, fruit, vegetable, and whole-grain intakes). Deaths were identified through the continuing medical care of participants and the National Death Index. An independent, blinded Event Adjudication Committee adjudicated causes of death. Cox regression models were used to estimate HRs of death during follow-up according to baseline dietary exposures and their yearly updated changes. Results: In up to 8.7 y of follow-up, 425 participants died. Baseline fiber intake and fruit consumption were significantly associated with lower risk of death [HRs for the fifth compared with the first quintile: 0.63 (95% CI: 0.46, 0.86; P = 0.015) and 0.59 (95% CI: 0.42, 0.82; P = 0.004), respectively]. When the updated dietary information was considered, participants with fruit consumption .210 g/d had 41% lower risk of all-cause mortality (HR: 0.59; 95% CI: 0.44, 0.78). Associations were strongest for CVD mortality than other causes of death. Conclusion: Fiber and fruit intakes are associated with a reduction in total mortality. PREDIMED was registered at controlled-trials.com as ISRCTN35739639. © 2014 American Society for Nutrition.
American Journal of Clinical Nutrition 100: 1498- 1507 (2014)
http://hdl.handle.net/10261/116363
10.3945/ajcn.114.093757
Cohort
Feeding trial
Tree nuts
Monounsaturated fat
Olive oil
Mediterranean diet
Dietary fiber intake
Fruit consumption
Mortality
Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study