2024-03-28T14:37:35Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1095792021-06-21T12:37:04Zcom_10261_81com_10261_5col_10261_334
00925njm 22002777a 4500
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Bautista-Aguilera, Óscar M.
author
Samadi, Abdelouahid
author
Chioua, Mourad
author
Nikolic, K.
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Filipic, S.
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Agbaba, Danica
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Soriano, Elena
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Andrés, L. de
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Rodríguez-Franco, María Isabel
author
Alcaro, S.
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Ramsay, R. R.
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Ortuso, F.
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Yáñez, Matilde
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Marco-Contelles, José
author
2014
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
Journal of Medicinal Chemistry 57: 10455-10463 (2014)
http://hdl.handle.net/10261/109579
10.1021/jm501501a
N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor