2024-03-28T21:26:24Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/809952019-10-03T12:20:40Zcom_10261_125com_10261_2col_10261_378
2013-08-26T06:38:41Z
urn:hdl:10261/80995
Human cecum content modulates production of extracellular proteins by food and probiotic bacteria
Sánchez García, Borja
Ruíz García, Lorena
Suárez, Adolfo
González de los Reyes-Gavilán, Clara
Margolles Barros, Abelardo
Ministerio de Ciencia e Innovación (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Lactic acid bacteria (LAB) are responsible for different types of food fermentations that provide humans with many different classes of fermented products. During the 20th century, some LAB strains as well as several members of the genus Bifidobacterium started to be extensively used in human nutrition as probiotics because of their health-promoting effects. Nowadays, the subset of extracellular proteins is being investigated as potential mediators of the process known as bacteria-host molecular crosstalk. Inclusion of human cecum extracts in laboratory culture medium modified the production of extracellular proteins by food and probiotic microorganisms. By proteomic and genetic means, the specific overproduction of two proteins was revealed to occur at transcriptional level. This work sheds light on the potential molecular effectors that food bacteria could use for interacting with the human gut and revealed that they may be produced under very specific environmental conditions. © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd.
2013-08-26T06:38:41Z
2013-08-26T06:38:41Z
2011-11
2013-08-26T06:38:41Z
artículo
FEMS Microbiology Letters 324(2): 189-194 (2011)
http://hdl.handle.net/10261/80995
10.1111/j.1574-6968.2011.02408.x
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003339
eng
closedAccess
Blackwell Publishing