2024-03-28T20:07:34Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/497562018-09-19T12:11:43Zcom_10261_69com_10261_2col_10261_322
2012-05-16T12:34:36Z
urn:hdl:10261/49756
Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats
Miguel, Marta
Gómez-Ruiz, José Ángel
Recio, Isidra
Aleixandre, Amaya
Angiotensin converting enzyme inhibitory activity
Food peptides
Hypertension
Milk proteins
Spontaneously hypertensive rats
6 páginas, 3 figuras, 1 tabla.
In this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from casein fractions, previously characterized as in vitro angiotensin-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The sequences LVYPFTGPIPN, HLPLP, IAK, YAKPVA and WQVLPNAVPAK showed a clear decrease in SBP and DBP in SHR. HPHPHLSF caused a significant decrease of the DBP in the SHR, but this sequence did not modify the SBP of these animals in a significant manner. KKYNVPQL did not modify SBP in the SHR, and caused a slight, but significant and maintained, decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. In conclusion, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension or other associated disorders.
2012-05-16T12:34:36Z
2012-05-16T12:34:36Z
2010-10
artículo
Molecular Nutrition and Food Research 54(10): 1422-1427 (2010)
1613-4125
http://hdl.handle.net/10261/49756
10.1002/mnfr.200900448
1613-4133
eng
http://dx.doi.org/10.1002/mnfr.200900448
closedAccess
Wiley-VCH