2024-03-29T04:46:27Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1807042020-10-15T10:15:49Zcom_10261_56com_10261_3com_10261_33com_10261_5col_10261_309col_10261_286
2019-04-29T10:48:52Z
urn:hdl:10261/180704
Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
Benito-Arenas, Raúl
Zárate, Sandra G.
Revuelta, Julia
Bastida, Agatha
Consejo Superior de Investigaciones Científicas (España)
Ministerio de Economía y Competitividad (España)
Iyases
Chondroitin sulfates
Glycosaminoglycan
Polysaccharides
Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications.
2019-04-29T10:48:52Z
2019-04-29T10:48:52Z
2019-04-01
2019-04-29T10:48:52Z
artículo
Catalysts 9(4): 322 (2019)
2073-4344
http://hdl.handle.net/10261/180704
10.3390/catal9040322
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100003329
Publisher's version
http://dx.doi.org/10.3390/catal9040322
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-65184-C2-2-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-79255-P
http://creativecommons.org/licenses/by-nc-sa/4.0/
openAccess
Multidisciplinary Digital Publishing Institute