2024-03-29T09:42:50Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/175222019-02-14T09:42:22Zcom_10261_72com_10261_6col_10261_325
2009-10-07T11:11:28Z
urn:hdl:10261/17522
Safety Evaluation of an Oak-Flavored Milk Powder Containing Ellagitannins upon Oral Administration in the Rat
Azorín-Ortuño, María
Urbán, Cristina
Cerón, José J.
Tecles, Fernando
Gil-Izquierdo, Ángel
Pallarés, Francisco J.
Tomás Barberán, Francisco
Espín de Gea, Juan Carlos
Consejo Superior de Investigaciones Científicas (España)
European Commission
Ellagitannin
Oak
Food safety
Xenobiotic
Ellagic
Toxicity
Urolithin
Tannin
Bioavailability
Metabolism
Tissue disposition
9 pages, 4 figures, 3 tables.
Ellagitannins are phenolic compounds that occur in a number of dietary sources such as walnuts, raspberries, pomegranate, strawberries, and oak-aged wines. Ellagitannins have been acknowledged to have antioxidant and cancer chemopreventive activities. However, ellagitannins have also been considered to be “antinutrients” and have been reported to provoke adverse effects in animals. In this context, risk assessment studies are demanded to ensure that chemicals present in food do not compromise food safety. Oak-flavored milk can be obtained by thermal treatment of milk in the presence of oak shavings. The oak-flavored milk can be used to impart wood-like flavor to different recipes. The present study evaluated, under a subchronic approach, the safety of an oak-flavored milk powder containing ellagitannins in rats upon repeated oral administration for 96 days. The effect of 30% oak-flavored milk powder in the diet was evaluated. This amount involved a margin of safety equivalent to the daily intake of 134 yogurts by a 70 kg person for 96 days. Growth rate, food utility index, 9 hematological, and 13 serobiochemical parameters as well as the metabolism and tissue distribution of ellagitannins and derived metabolites were studied. Overall, no significant differences were found in oak-milk-fed rats in any blood parameter analyzed. No effect was found on growth rate and food utility index. Urolithin A was identified in feces of rats fed oak-flavored milk and the glucuronide derivative in urine. No metabolites were found in the liver, kidney, or uterus. Histopathological analysis of liver and kidney corroborated the absence of toxicity. Therefore, these results suggest that the intake of the oak-flavored milk powder assayed in this study is safe and does not involve potential hazard to human health.
2009-10-07T11:11:28Z
2009-10-07T11:11:28Z
2008-03-28
artículo
Journal of Agricultural and Food Chemistry 56(8): 2857-2865 (2008)
0021-8561
http://hdl.handle.net/10261/17522
10.1021/jf8000857
1520-5118
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100000780
eng
http://dx.doi.org/10.1021/jf8000857
closedAccess
American Chemical Society