2024-03-28T22:35:42Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1719702022-11-22T13:51:50Zcom_10261_108com_10261_8col_10261_361
2018-11-07T09:36:24Z
urn:hdl:10261/171970
Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases
Cabezas-Cruz, Alejandro
Mateos-Hernández, Lourdes
Alberdi, Pilar
Villar, Margarita
Riveau, Gilles
Hermann, Emmanuel
Schacht, Anne-Marie
Khalife, Jamal
Correia-Neves, Margarida
Gortázar, Christian
Fuente, José de la
European Commission
The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Galα1-3Galß1-(3)4GlcNAc-R (α-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to α-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying α-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with α-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without α-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-α-Gal antibody protective response. These results have implications for disease control and prevention.
2018-11-07T09:36:24Z
2018-11-07T09:36:24Z
2017
2018-11-07T09:36:25Z
artículo
Experimental and Molecular Medicine 49(3): e301 (2017)
http://hdl.handle.net/10261/171970
10.1038/emm.2016.164
http://dx.doi.org/10.13039/501100000780
28280265
eng
Publisher's version
https://doi.org/10.1038/emm.2016.164
Sí
info:eu-repo/grantAgreement/EC/FP7/278976
info:eu-repo/grantAgreement/EC/H2020/643476
http://creativecommons.org/licenses/by-nc-nd/4.0/
openAccess
Nature Publishing Group