2024-03-29T08:01:52Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1650162021-12-28T16:39:23Zcom_10261_13com_10261_8col_10261_266
2018-05-24T08:51:02Z
urn:hdl:10261/165016
First cases of European bat lyssavirus type 1 in Iberian serotine bats: Implications for the molecular epidemiology of bat rabies in Europe
Mingo-Casas, Patricia
Sandonís, Virginia
Obón, Elena
Berciano, José M.
Vázquez-Morón, Sonia
Juste, Javier
Echevarría, Juan E.
Previous studies have shown that EBLV-1 strains exclusively hosted by Eptesicus isabellinus
bats in the Iberian Peninsula cluster in a specific monophyletic group that is related to
the EBLV-1b lineage found in the rest of Europe. More recently, enhanced passive surveillance
has allowed the detection of the first EBLV-1 strains associated to Eptesicus serotinus
south of the Pyrenees. The aim of this study is the reconstruction of the EBLV-1 phylogeny
and phylodynamics in the Iberian Peninsula in the context of the European continent. We
have sequenced 23 EBLV-1 strains detected on nine E. serotinus and 14 E. isabellinus.
Phylogenetic analyses were performed on the first 400-bp-5' fragment of the Nucleoprotein
(N) gene together with other 162 sequences from Europe. Besides, fragments of the variable
region of the phosphoprotein (P) gene and the glycoprotein-polymerase (G-L) intergenic
region were studied on Spanish samples. Phylogenies show that two of the new
EBLV-1a strains from Iberian E. serotinus clustered together with French strains from the
North of the Pyrenees, suggesting a recent expansion southwards of this subtype. The
remaining seven Iberian strains from E. serotinus grouped, instead, within the cluster linked,
so far, to E. isabellinus, indicating that spatial distribution prevails over species specificity in
explaining rabies distribution and supporting interspecific transmission. The structure found
within the Iberian Peninsula for EBLV-1b is in concordance with that described previously
for E. isabellinus. Finally, we have found that the current EBLV-1 European strains could
have emerged only 175 years ago according to our evolutionary dynamics analyses
2018-05-24T08:51:02Z
2018-05-24T08:51:02Z
2018
artículo
PLoS Neglected Tropical Diseases, 12(4): e000629 (2018)
http://hdl.handle.net/10261/165016
10.1371/journal.pntd.0006290
29684025
eng
Publisher's version
htpp://dx.doi.org/10.1371/journal.pntd.0006290
Sí
http://creativecommons.org/licenses/by/4.0/.
openAccess
Public Library of Science