2024-03-28T23:57:50Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1505642021-07-28T12:07:09Zcom_10261_31891com_10261_2com_10261_125col_10261_31892col_10261_378
2017-05-29T09:37:12Z
urn:hdl:10261/150564
Adherence to a Mediterranean diet influences the fecal metabolic profile of microbial-derived phenolics in a Spanish cohort of middle-age and older people
Gutiérrez-Díaz, Isabel
Fernández-Navarro, Tania
Salazar, Nuria
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
González de los Reyes-Gavilán, Clara
Gueimonde Fernández, Miguel
González Solares, Sonia
European Commission
Ministerio de Economía y Competitividad (España)
Principado de Asturias
Biopolis
Ministerio de Ciencia e Innovación (España)
Fecal metabolites excretion
Physical activity
Phenolic compounds
Mediterranean dietary pattern
Fiber
Despite the evidence regarding the influence of certain polyphenol food sources on the metabolic profile in feces, the association between the different phenolics provided by the diet and the fecal phenolic profile has not been elucidated. In this study, the composition of phenolic metabolites in fecal solutions was analyzed by UPLC-ESI-MS/MS in 74 volunteers. This fecal phenolic profile showed a high interindividual variation of the different compounds analyzed, phenylacetic and phenylpropionic acids being the major classes of phenolic metabolites excreted in feces. Subjects with higher adherence to a Mediterranean dietary pattern presented greater fecal concentrations of benzoic and 3-hydroxyphenylacetic acids, positively correlated with the intake of the principal classes and subclasses of polyphenols and fibers, and higher levels of Clostridium cluster XVIa and Faecalibacterium prausnitzii. These results provide a link among the Mediterranean dietary pattern, the bioactive compounds of the diet, and the fecal metabolic phenolic profile.
2017-05-29T09:37:12Z
2017-05-29T09:37:12Z
2017
2017-05-29T09:37:12Z
artículo
Journal of Agricultural and Food Chemistry 65(3): 586-595 (2017)
http://hdl.handle.net/10261/150564
10.1021/acs.jafc.6b04408
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/100011941
eng
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64522-C2-1-R
closedAccess
American Chemical Society