2024-03-29T08:03:47Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1456502022-10-04T15:04:29Zcom_10261_47com_10261_8com_10261_94col_10261_300col_10261_347
2017-02-23T11:39:22Z
urn:hdl:10261/145650
POMC: An evolutionary perspective
Navarro, Sandra
Soletto, L.
Puchol, Sara
Rotllant, Josep
Soengas, José L.
Cerdá-Reverter, José Miguel
ACTH
β-endorphin
Opioid
Evolution
MSH
Proopiomelanocortin
Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event. POMC underwent complex evolutionary processes, including internal tandem duplications and putative coevolutionary events. Controversial and conflicting hypotheses have emerged concerning the sequenced genomes. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.
2017-02-23T11:39:22Z
2017-02-23T11:39:22Z
2016-05-01
2017-02-23T11:39:22Z
artículo
Journal of Molecular Endocrinology 56: T113-T118 (2016)
http://hdl.handle.net/10261/145650
10.1530/JME-15-0288
eng
Postprint
https://doi.org/10.1530/JME-15-0288
Sí
closedAccess
Society for Endocrinology