2024-03-29T07:13:40Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1399672021-12-27T15:37:35Zcom_10261_109com_10261_1col_10261_362
2016-11-09T11:30:26Z
urn:hdl:10261/139967
Is Hybridization a Source of Adaptive Venom Variation in Rattlesnakes? A Test, Using a Crotalus scutulatus × viridis Hybrid Zone in Southwestern New Mexico
Zancolli, Giulia
Bake, Timothy G.
Barlow, Axel
Bradley, Rebecca K.
Calvete, Juan J.
Carter, Kimberley C.
Jager, Kaylah de
Owens, John Benjamin
Price, Jenny Forrester
Sanz, Libia
Scholes-Higham, Amy
Shier, Liam
Wood, Liam
Wüster, Catharine E.
Wüster, Wolfgang
Ministerio de Economía y Competitividad (España)
Adaptation
Crotalus
Evolution
Hybridization
Introgression
Mojave toxin
Molecular evolution
Venom
Artículo electrónico, 16 páginas, 5 figuras, 4 tablas (2 en material suplementario).
Venomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter- and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A₂ such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genes document extensive admixture within a narrow hybrid zone. The genes encoding the two MTX subunits are strictly linked, and found in most hybrids and backcrossed individuals, but not in C. viridis away from the hybrid zone. Presence of the genes is invariably associated with presence of the corresponding toxin in the venom. We conclude that introgression of highly lethal neurotoxins through hybridization is not necessarily favored by natural selection in rattlesnakes, and that even extensive hybridization may not lead to introgression of these genes into another species.
2016-11-09T11:30:26Z
2016-11-09T11:30:26Z
2016-06-16
artículo
Toxins 8(6): E188 (2016)
http://hdl.handle.net/10261/139967
10.3390/toxins8060188
2072-6651
http://dx.doi.org/10.13039/501100003329
27322321
eng
Publisher's version
http://dx.doi.org/10.3390/toxins8060188
Sí
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-42833-P
openAccess
Molecular Diversity Preservation International