2024-03-28T11:43:05Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1341572021-12-28T16:30:17Zcom_10261_112com_10261_1col_10261_365
2016-06-28T11:18:34Z
urn:hdl:10261/134157
Common Infectious Agents and Monoclonal B-Cell Lymphocytosis: A Cross-Sectional Epidemiological Study among Healthy Adults
Casabonne, Delphine
Almeida, Julia
Nieto, Wendy G.
Rodríguez-Caballero, Arancha
Orfao, Alberto
Red Temática de Investigación Cooperativa en Cáncer (España)
Instituto de Salud Carlos III
Ministerio de Economía y Competitividad (España)
Junta de Castilla y León
Asociación Española Contra el Cáncer
Generalitat de Catalunya
Instituto de Salud Carlos III
This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- Primary Health Care Group of Salamanca for the Study of MBL: et al.
[Background]: Risk factors associated with monoclonal B-cell lymphocytosis (MBL), a potential precursor of chronic lymphocytic leukaemia (CLL), remain unknown. [Methods]: Using a cross-sectional study design, we investigated demographic, medical and behavioural risk factors associated with MBL. >Low-count> MBL (cases) were defined as individuals with very low median absolute count of clonal B-cells, identified from screening of healthy individuals and the remainder classified as controls. 452 individuals completed a questionnaire with their general practitioner, both blind to the MBL status of the subject. Odds ratios (OR) and 95% confidence interval (CI) for MBL were estimated by means of unconditional logistic regression adjusted for confounding factors. [Results]: MBL were detected in 72/452 subjects (16%). Increasing age was strongly associated with MBL (P-trend<0.001). MBL was significantly less common among individuals vaccinated against pneumococcal or influenza (OR 0.49, 95% confidence interval (CI): 0.25 to 0.95; P-value = 0.03 and OR: 0.52, 95% CI: 0.29 to 0.93, P-value = 0.03, respectively). Albeit based on small numbers, cases were more likely to report infectious diseases among their children, respiratory disease among their siblings and personal history of pneumonia and meningitis. No other distinguishing epidemiological features were identified except for family history of cancer and an inverse relationship with diabetes treatment. All associations described above were retained after restricting the analysis to CLL-like MBL. [Conclusion]: Overall, these findings suggest that exposure to infectious agents leading to serious clinical manifestations in the patient or its surroundings may trigger immune events leading to MBL. This exploratory study provides initial insights and directions for future research related to MBL, a potential precursor of chronic lymphocytic leukaemia. Further work is warranted to confirm these findings.
2016-06-28T11:18:34Z
2016-06-28T11:18:34Z
2012
2016-06-28T11:18:34Z
artículo
PLoS ONE 7(12): e52808 (2012)
http://hdl.handle.net/10261/134157
10.1371/journal.pone.0052808
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100002809
http://dx.doi.org/10.13039/501100004587
http://dx.doi.org/10.13039/501100014180
23285188
eng
Publisher's version
http://dx.doi.org/10.1371/journal.pone.0052808
Sí
http://creativecommons.org/licenses/by/4.0/
openAccess
Public Library of Science